General Information

  • ID:  hor005167
  • Uniprot ID:  P18144
  • Protein name:  Natriuretic peptides A
  • Gene name:  nppa
  • Organism:  Anguilla japonica (Japanese eel)
  • Family:  natriuretic peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anguilla (genus), Anguillidae (family), Anguilliformes (order), Elopomorpha, Elopocephala, Elopocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006182 cGMP biosynthetic process; GO:0007168 receptor guanylyl cyclase signaling pathway; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SKSSSPCFGGKLDRIGSYSGLGCNSRK
  • Length:  27
  • Propeptide:  SKSSSPCFGGKLDRIGSYSGLGCNSRK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  vasodepressor activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  7-23
  • Structure ID:  AF-P18144-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P18144-F1.pdbhor005167_AF2.pdbhor005167_ESM.pdb

Physical Information

Mass: 325605 Formula: C116H191N37O39S2
Absent amino acids: AEHMQTVW Common amino acids: S
pI: 10.14 Basic residues: 5
Polar residues: 16 Hydrophobic residues: 4
Hydrophobicity: -67.78 Boman Index: -6079
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 3966.67 Extinction Coefficient cystines: 1615
Absorbance 280nm: 62.12

Literature

  • PubMed ID:  2529857
  • Title:  Amino acid sequence and relative biological activity of eel atrial natriuretic peptide.